Filming Location
127A Smithfield Road, Frederiksted, Virgin Islands
20 NDC - Detalhes da reação entre o peroxinitrito e PDI
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Description
The TV series 20 NDC - Detalhes da reação entre o peroxinitrito e PDI, created by an unlisted creator and produced by an unlisted studio, first premiered on March 14, 2018 in the United Kingdom. The series spans 1 season with 3 episodes, featuring the voices of an unlisted voice cast. It follows the story of Doenças como o mal de Alzheimer, de Parkinson, e catarata ocular estão associadas ao fato de as proteínas das células perderem sua estrutura. Com isso, formam agregados que são tóxicos. Esse processo pode ser desencadeado por oxidantes biológicos, isto é, moléculas capazes de captar elétrons das proteínas, o que leva a mudanças em sua estrutura. Pesquisadores do Centro de Pesquisa sobre Processos Redox em Biomedicina (Cepid Redoxoma), sediado no Instituto de Química da USP, estudaram os detalhes da reação entre um desses oxidantes biológicos, o peroxinitrito, e a proteína PDI - que se agrega quando encontra o peroxinitrito. This is an Other series and has received a rating of 0/10 from 0 viewers.
Where to Watch
ugc-edu.comTIMA
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Production
Castle Rock Entertainment
Award
21 wins & 43 nominations total
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User Review
O peroxinitrito é um potente agente oxidante formado pela reação entre o óxido nítrico e o ânion superóxido. Ele pode induzir a agregação da PDI, e também modificar a estrutura dela através de uma reação chamada "nitração". Reportagem: Tabita Said, Ignacio Amigo, Isabella Yoshimura. Edição: Tabita Said, Ignacio Amigo, Lucca Chiavone e Rafael Simões.
Os pesquisadores do Instituto de Química da USP determinaram a velocidade da reação entre a PDI e o peroxinitrito, um dado que não era conhecido e que pode ajudar a entender melhor o papel dessa reação no seu contexto biológico. Reportagem: Tabita Said, Ignacio Amigo, Isabella Yoshimura. Edição: Tabita Said, Ignacio Amigo, Lucca Chiavone e Rafael Simões.
Muitas doenças estão associadas à perda de estrutura de proteínas e formação de agregados tóxicos. Oxidantes biológicos podem levar às proteínas a agregar. Pesquisadores do Centro de Pesquisa sobre processos Redox em Biomedicina (Cepid Redoxoma), sediado no Instituto de Química da USP, estudaram os detalhes da reação entre um desses oxidantes biológicos, o peroxinitrito, e a proteína PDI -- que se agrega quando encontra o peroxinitrito. Reportagem: Tabita Said, Ignacio Amigo, Isabella Yoshimura. Edição: Tabita Said, Ignacio Amigo, Lucca Chiavone e Rafael Simões.
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